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It is recommended that you disconnect/remove all M-Audio devices from your system before performing a major operating system update. Updating your OS can alter product driver files or cause temporary voltage fluctuations in you system, which could potentially cause a number of different problems with your M-Audio device.
If you are using a Windows system, installing a new Microsoft Service Pack would be considered an update significant enough to warrant temporarily removing your M-Audio hardware.
If you are using Mac OS X, moving up one or more OS X version numbers (from 10.4.5 to 10.4.6, for example) would be considered an update significant enough to justify temporarily removing your M-Audio hardware.