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Pro Tools SE will not work with the speakers/sound card built into your computer. Pro Tools SE requires the included M-Audio sound card/audio interface (e.g. Micro USB, Producer USB, MobilePre, Fast Track) for audio input and output. Please connect your speakers and/or headphones to the M-Audio sound card.
Note: On Mac OS X, the Pro Tools SE quick-start program if Adobe Flash based and will playback through the system default output device, which may be your built-in sound card/speakers. To change this, go to Apple's System Preferences > Sound > Output tab and select your M-Audio device.