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Older M-Audio ProFire and FireWire Series drivers that were available prior to the release of Mac OS X 10.7 (Lion) are not compatible with the new Mac OS X 10.7 operating system update. If these drivers are installed when updating to Mac OS X 10.7, they will be moved to a folder named "Incompatible Software" and cannot be used on 10.7.
See this article for more information about Incompatible Software: http://support.apple.com/kb/ht3258
Updated Mac OS X 10.7 (Lion) compatible drivers for ProFire 610 and ProFire 2626 are available at www.m-audio.com/drivers.
Updated Mac OS X 10.7 (Lion) compatible drivers for FireWire Audiophile, FireWire Solo, FireWire 410, FireWire 1814, NRV10, Ozonic, ProFire Lightbridge, and ProjectMix I/O are available at www.m-audio.com/drivers.