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The use of USB Audio Devices on the USB port closest to the screen is not recommended. This applies to all White and Black MacBook Models (Core Duo and Core 2 Duo). This does not apply to the newer Aluminum Uni-Body MacBook's.
There are 2 USB ports on the left side of the MacBook models. Due to the current USB configuration of the MacBook under OS X, the use of USB audio devices is supported on the front USB port only (the port farthest away from the screen). Use of such devices on the rear USB port is not advised because it may cause audio interrupts and/or dropped samples. However, the use of an iLok dongle on the rear port has been qualified and is fully supported.
These USB port recommendations are specific to USB Audio devices only (such as the Audiophile USB). USB Keyboard and Control Surface products do not have a recommended USB port at this time.